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Tructures on binding. 2.4 Self-Assembly of IDPs IDPs frequently undergo self-assembly. The extended conformation of IDPs facilitates the intermolecular interactions between them and promotes formation of supramolecular architecture [109]. This is illustrated in some of the mineralized tissues discussed above. Silaffins, for example, are protein constituents of biosilica, playing an active role in
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, I54A 32, a very stable mutant, is more susceptible to ClpYQ and FtsH proteases than wild-type 32, indicating that the stability of 32 does not always reflect its susceptibility to proteases. Co-precipitation and gel filtration analyses show that purified 32 mutants exhibit a reduced affinity for DnaJ, leading to a marked decrease in forming a complex with DnaK in the presence of DnaJ and ATP. Ot
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Tructures on binding. 2.4 Self-Assembly of IDPs IDPs frequently undergo self-assembly. The extended conformation of IDPs facilitates the intermolecular interactions between them and promotes formation of supramolecular architecture [109]. This is illustrated in some of the mineralized tissues discussed above. Silaffins, for example, are protein constituents of biosilica, playing an active role in
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Ancer Ther 2002, 1:483?92. Ramsay G, Evan GI, Bishop JM: The protein encoded by the human proto-oncogene c-myc. Proc Natl Acad Sci U S A 1984, 81:7742?746. Gregory MA, Hann SR: c-myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-myc in burkitt's lymphoma cells. Mol Cell Biol 2000, 20:2423?435. Lameh J, Chuang LF, Israel M, Chuang RY: Mechanistic studies on N-benzyladriamycin-
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Ytoplasm. It is known to degrade some cytoplasmic proteins as well as membrane proteins (7). Although FtsH is essential for growth, a ftsH strain can be isolated if the cell simultaneously contains an unusually high activity of R-3-hydroxyacyl-ACP dehydrase (encoded by the fabZ gene) (8). The major function of FtsH is the maintenance of the proper lipopolysaccharide/ phospholipids ratio by the deg
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To protein Variable degree of carrier immunogenicity; need adjuvants (and oftenTo protein Variable degree of carrier immunogenicity; need adjuvants (and often multiple doses); frequent local reactions at the injection siteHumoral immunityDiphtheria; tetanus; pertussis; haemophilus influenzae type b; poliomyelitis; rabies; meningitidis; Japanese encephalitis; cholera; hepatitis A; hepatitis B
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To protein Variable degree of carrier immunogenicity; need adjuvants (and oftenTo protein Variable degree of carrier immunogenicity; need adjuvants (and often multiple doses); frequent local reactions at the injection siteHumoral immunityDiphtheria; tetanus; pertussis; haemophilus influenzae type b; poliomyelitis; rabies; meningitidis; Japanese encephalitis; cholera; hepatitis A; hepatitis B
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