Ectable peptidase domain, but it has a novel domain belonging to the Der1-like family (Pfam PF04511 with E=3.4e-17). The Der1 protein is thought to play an indispensable role in the degradation process associated with the endoplasmic reticulum (ER) (Knop et al. 1996). Although there is no direct evidence of its proteolytic activity, this family may be distantly related to the rhomboid protease fam