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Large structural scaffold formed by the multi-domain core enzyme, E2, aLarge structural scaffold formed by the multi-domain core enzyme, E2, a specific dihydrolipoyl acetyltransferase. The E2 polypeptide chain is composed of three independently folded domains separated by flexible linker regions: a lypoil domain (LD) of 9.5 kDa, a peripheral (E1 and/or E3) subunit-binding domain (PSBD) of 5.