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Pressing dominant negative (V53D) versus wild-type (WT) b-arrestin-1. There was no inhibitory effect of the dominant negative b-arrestin-1 on ERK1/2 activation, suggesting that, unlike several other GPCRs (Cottrell et al., 2009; Luttrell and Gesty-Palmer, 2010), the RXFP3/b-arrestin-1 interaction contributes little to ERK1/2 signaling (Kocan et al., 2014). Previous studies demonstrated internaliza