S between RXFP3 and b-arrestins occur after administration of human relaxin-3 but not relaxin or the RXFP3 antagonist R3 (BD23?7)R/I5 as measured by real-time kinetic BRET between RXFP3-Rluc8 and a b-arrestin fusion protein (b-arrestin-1-Venus or b-arrestin-2-Venus). Preincubation with R3(BD2327)R/I5 completely inhibits the human relaxin-3 stimulated recruitment of b-arrestin-1 and b-arrestin-2 to


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