SMT Discover - 70 chaperone system consists of Hsp70, Hsp40, and a nucleotide exchange factor http://discover.societymusictheory.org/story.php?title=70-chaperone-system-consists-of-hsp70-hsp40-and-a-nucleotide-exchange-factor-505 70 chaperone system consists of Hsp70, Hsp40, and a nucleotide exchange factor (Hsp70 has an ATPase activity). Although the ATP-bound form of Hsp70 has a low affinity for substrates due to its high substrate exchange rate, the ADP-bound form has a higher affinity for substrates with a low substrate exchange rate. Hsp40 acts as a co-chaperone and activates the Hsp70 ATPase, although it also acts as Tue, 25 Jun 2019 01:23:58 UTC en