SMT Discover - As the search model. The wild type SHP2 and D61G http://discover.societymusictheory.org/story.php?title=as-the-search-model-the-wild-type-shp2-and-d61g-139 As the search model. The wild type SHP2 and D61G, E139D, Y279C and Q506P mutant structures were determined by molecular replacement, using the structure of the N308D SHP2 mutant as a search model. Following the initial rigid body refinement, interactive cycles of model building and refinement were performed by using COOT [40] and Buster-TNT [41] software. Special attention was paid to the mutation Wed, 20 Feb 2019 19:43:29 UTC en