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Described experiments. SM performed real-time PCR analysis of EGR2, CD163, and HLA-DRA in human mammary explant tissue and performed data analysis. SS participated in the study design, edited the manuscript, and gave final approval of the version to be published. All authors read and approved the final manuscript. Competing interests The authors do not have any financial or personal relationships
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Described experiments. SM performed real-time PCR analysis of EGR2, CD163, and HLA-DRA in human mammary explant tissue and performed data analysis. SS participated in the study design, edited the manuscript, and gave final approval of the version to be published. All authors read and approved the final manuscript. Competing interests The authors do not have any financial or personal relationships
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Noted in atypical breast lesions [49, 50]. Our studies suggest that loss of SFRP1 in epithelial cells can enhance TGF- mediated EGR2 expression and affect TGF- induced M2 polarization of macrophages. As M2 macrophages secrete growth factors, such as Wnt ligands and EGF, this could contribute to tumor progression through a feed forward cross talk between the epithelium and the immune system. Additi
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Ey MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A. 1997;94(13):6770-6775. PubMed 2. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests a
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Ey MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A. 1997;94(13):6770-6775. PubMed 2. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests a
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G of human mammary stem/progenitor cells. Genes Dev. 2003;17(10):1253-1270. PubMed. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162(1):156-159. PubMed.Gregory et al. BMC Cancer (2017) 17:Page 10 of25. Dillon RL, Brown ST, Ling C, Shioda T, Muller WJ. An EGR2/CITED1 transcription factor complex and the
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E harvests for real-time PCR analysis of Egr2. All real-time PCR results are from two separate experiments performed in triplicate and results were normalized to amplification of ACTB mRNA. Bars represent mean ?SEM and are expressed as fold change with respect DMSO treated cells. *p < 0.05, **p < 0.01 (significantly different from DMSO treated group using student's t-test). (PDF 163 kb)Gregory et
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E harvests for real-time PCR analysis of Egr2. All real-time PCR results are from two separate experiments performed in triplicate and results were normalized to amplification of ACTB mRNA. Bars represent mean ?SEM and are expressed as fold change with respect DMSO treated cells. *p < 0.05, **p < 0.01 (significantly different from DMSO treated group using student's t-test). (PDF 163 kb)Gregory et