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Ivered between gestational days 20 and 34, which is when extravillous trophoblasts display the maximal decidual penetration [37]; thus the secondary fetal losses may be attributed to decreased decidual vasodilatation, hyperpermeability, and priming of the spiral arteries [41]. The retardation of trophoblast invasion, reflected at term by a reduction of endovascular trophoblasts in viable feto-plac
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O, an intricate vasodilatory/pleiotropic network and tissue-specific effects could diminish the effects of angiotensin II stimulation and B2R blockade. The presently observed persistent changes in trophoblast invasion partially confirm our hypothesis that disturbing the endogenous balance between the RAS and the KKS in mid-pregnancy would provoke a defectiveVald et al. Reproductive Biology and En
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte
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Independent determinants of apelin-36 levels (Table 4). When this analysis was repeated dividing the patients into two groups according to the presence of hypertension; diastolic blood pressure (B = 0.001, beta = 0.42, p = 0.002), LDL-cholesterol (B = 0.003, beta = 0.35, p = 0.021) and EF (B = 0.01, beta = 0.27, p = 0.049) remained as the determinants in hypertensive group; while ALP (B = 0.001, b
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Independent determinants of apelin-36 levels (Table 4). When this analysis was repeated dividing the patients into two groups according to the presence of hypertension; diastolic blood pressure (B = 0.001, beta = 0.42, p = 0.002), LDL-cholesterol (B = 0.003, beta = 0.35, p = 0.021) and EF (B = 0.01, beta = 0.27, p = 0.049) remained as the determinants in hypertensive group; while ALP (B = 0.001, b
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F intermediate effectors.7.Conclusions By transiently tilting the balance of the opposing RAS and KKS systems during the period of maximal trophoblast invasion, we demonstrated deleterious effects of AII and B2R blockade in pregnant guinea-pigs. Further understanding of the effects of the opposing RAS and KKS could inspire the development of pharmacological interventions to enhance the KKS in orde
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Tudy parameters. The discordance between the lack of additive effect on fetal weight and the summatory impact on the fetal/placental weight ratio could be because the combined intervention induces greater fetal losses, which favor the growth of the remaining units. The higher plasma creatinine in dams that received BDZ--absent in the AII + BDZ group--could be attributed to a lack of the protective
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte