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Ns [26,32,42-45]. However, the deleterious effects of AT1R antagonists in pregnancy [46,47] preclude their use for identifying the main receptor stimulated by excess angiotensin. The acute effect of angiotensin II plus a B2R blocker provoked an increase of systolic blood pressure in a subset of the group (responders) to values that were not attained with single interventions and in non-pregnant fe
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Tudy parameters. The discordance between the lack of additive effect on fetal weight and the summatory impact on the fetal/placental weight ratio could be because the combined intervention induces greater fetal losses, which favor the growth of the remaining units. The higher plasma creatinine in dams that received BDZ--absent in the AII + BDZ group--could be attributed to a lack of the protective
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Al spiral arteries are depicted in the upper and lower panel, respectively. The whole-mount haematoxylin/eosin section of the guinea-pig utero-placental interface includes in blue ovals the zones from which the microphotographs were acquired; trophoblasts were identified by anti-cytokeratin and highlighted by * and interrupted lines. Magnification x400 in upper panel and x100 in lower panel.tropho
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Al spiral arteries are depicted in the upper and lower panel, respectively. The whole-mount haematoxylin/eosin section of the guinea-pig utero-placental interface includes in blue ovals the zones from which the microphotographs were acquired; trophoblasts were identified by anti-cytokeratin and highlighted by * and interrupted lines. Magnification x400 in upper panel and x100 in lower panel.tropho
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Ingle interventions (0.38 ?0.02 andABB*Figure 1 Systolic blood pressure in pregnant and non-pregnant guinea-pigs treated with angiotensin II (AII), bradyzide (BDZ), or AII + BDZ. Systolic blood pressure on gestational days 34 (A) and 60 (B) in controls (C), AII, BDZ and AII + BDZ treated dams and in AII + BDZ-treated non-pregnant females (AII + BDZ NP). The broken line depicts the mean systolic bl
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Myometrial spiral arteries, the perimeter occupied by endoluminal EVT was reduced in the groups receiving AII, BDZ, (P < 0.0005 for both) and AII + BDZ (P < 0.005) as compared to controls. (Figure 3B). In summary, both the isolated and combined interventions resulted in reductions of endoluminal EVT in lateral and myometrial spiral arteries as depicted in Figure 4, upper and lower panel, respectiv
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte
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Independent determinants of apelin-36 levels (Table 4). When this analysis was repeated dividing the patients into two groups according to the presence of hypertension; diastolic blood pressure (B = 0.001, beta = 0.42, p = 0.002), LDL-cholesterol (B = 0.003, beta = 0.35, p = 0.021) and EF (B = 0.01, beta = 0.27, p = 0.049) remained as the determinants in hypertensive group; while ALP (B = 0.001, b