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The statistical analysis and performed the Bayesian statistics. With the exception of deceased JC, all authors read and approved the final manuscript. Acknowledgements This study was financed by Fondecyt 1080228 and 1121161. The authors are indebted to Ms. Marta D z and Eliana Lira for their contributions in the care and mating of the animals, and the preparation of the histological sections. Auth
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte
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Tudy parameters. The discordance between the lack of additive effect on fetal weight and the summatory impact on the fetal/placental weight ratio could be because the combined intervention induces greater fetal losses, which favor the growth of the remaining units. The higher plasma creatinine in dams that received BDZ--absent in the AII + BDZ group--could be attributed to a lack of the protective
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Tudy parameters. The discordance between the lack of additive effect on fetal weight and the summatory impact on the fetal/placental weight ratio could be because the combined intervention induces greater fetal losses, which favor the growth of the remaining units. The higher plasma creatinine in dams that received BDZ--absent in the AII + BDZ group--could be attributed to a lack of the protective
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte
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Treated with saline, AII, BDZ, or AII + BDZ. (B) Myometrial spiral artery endothelium replaced by EVT ( perimeter) in dams treated with saline, AII, BDZ, or AII + BDZ. Continuous line represents mean values. **P < 0.005; ***P < 0.0005.Discussion The results of the present study indicate that a transient disruption of the balance between the RAS and the KKS in favor of the RAS in midpregnancy alte
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Ivered between gestational days 20 and 34, which is when extravillous trophoblasts display the maximal decidual penetration [37]; thus the secondary fetal losses may be attributed to decreased decidual vasodilatation, hyperpermeability, and priming of the spiral arteries [41]. The retardation of trophoblast invasion, reflected at term by a reduction of endovascular trophoblasts in viable feto-plac
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Ivered between gestational days 20 and 34, which is when extravillous trophoblasts display the maximal decidual penetration [37]; thus the secondary fetal losses may be attributed to decreased decidual vasodilatation, hyperpermeability, and priming of the spiral arteries [41]. The retardation of trophoblast invasion, reflected at term by a reduction of endovascular trophoblasts in viable feto-plac